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Fibroblast Growth Factor Receptor (FGFR) pathway plays an important role in the occurrence and development of many tumors. The panFGFx was independently developed by MEDx Translational Medicine to detect genes of FGFRs, the upstream FGFs ligand genes and downstream pathway genes. It can be utilized to analyze various types of mutations such as point mutations, insertion/deletion, fusion, amplification, etc. It is also used for Powerful FGF-FGFR pathway biomarker research and the development of companion diagnostics.
NGS
√Highly targeted: a "small but refined" panel for FGFR inhibitor TKI drug research, focusing on FGFR and key genes in the upstream and downstream signaling pathways;
√Wide application: small panel, low cost; combined with enzyme digestion method and rapid hybridization method to shorten TAT;
√Strong flexibility: the probe can realize physical module distinction, and meet the development needs of companion diagnostic products at any time;
√Focused on FGFR detection: FGFR1-4 probes cover all the exons of genes, including UTR region, with the most complete coverage, and it can detect SNV/InDel, Fusion, and CNV with high sensitivity；
Pan-cancer species
FGFR Ligand gene | ||||||||
FGF1 | FGF2 | FGF3 | FGF4 | FGF5 | FGF6 | FGF7 | FGF8 | FGF9 |
FGF10 | FGF12 | FGF14 | FGF17 | FGF18 | FGF19 | FGF23 | ||
FGFR Gene | ||||||||
FGFR1 | FGFR2 | FGFR3 | FGFR4 | |||||
FGFR Downstream signaling pathway genes | ||||||||
AKT1 | AKT2 | AKT3 | MTOR | PIK3CA | PIK3CB | PIK3CD | PTEN | ARAF |
BRAF | HRAS | KRAS | MAP2K1 | MAP2K2 | MAPK1 | MAPK3 | NRAS | RAF1 |
SOS1 | STAT3 | |||||||
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