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Custom Products for FGFR Inhibitor Research(panFGFx)

Fibroblast Growth Factor Receptor (FGFR) pathway plays an important role in the occurrence and development of many tumors. The panFGFx was independently developed by MEDx Translational Medicine to detect genes of FGFRs, the upstream FGFs ligand genes and downstream pathway genes. It can be utilized to analyze various types of mutations such as point mutations, insertion/deletion, fusion, amplification, etc. It is also used for Powerful FGF-FGFR pathway biomarker research and the development of companion diagnostics.

Technical method

NGS

Product advantages

√Highly targeted: a "small but refined" panel for FGFR inhibitor TKI drug research, focusing on FGFR and key genes in the upstream and downstream signaling pathways;

√Wide application: small panel, low cost; combined with enzyme digestion method and rapid hybridization method to shorten TAT;

√Strong flexibility: the probe can realize physical module distinction, and meet the development needs of companion diagnostic products at any time;

√Focused on FGFR detection: FGFR1-4 probes cover all the exons of genes, including UTR region, with the most complete coverage, and it can detect SNV/InDel, Fusion, and CNV with high sensitivity;

Applicable cancer

Pan-cancer species

Table

FGFR Ligand gene

FGF1

FGF2

FGF3

FGF4

FGF5

FGF6

FGF7

FGF8

FGF9

FGF10

FGF12

FGF14

FGF17

FGF18

FGF19

FGF23

FGFR Gene

FGFR1

FGFR2

FGFR3

FGFR4

FGFR Downstream signaling pathway genes

AKT1

AKT2

AKT3

MTOR

PIK3CA

PIK3CB

PIK3CD

PTEN

ARAF

BRAF

HRAS

KRAS

MAP2K1

MAP2K2

MAPK1

MAPK3

NRAS

RAF1

SOS1

STAT3

If you have any of the following needs, feel free to contact us or email us at inquiry@MEDxTMC.net . We will reply within 24 hours.


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