Proteomics Center

A complete immunoprotein analysis platform at MEDx has been successfully established since 2017 including ELISA and MSD platforms for PD/PK/ADA clinical study, and Western Blot (WB) platform for drug signal pathway study. The center is equipped with Biorad V3 WB Detection System, BioTek 405 LS Automatic Microplate Washing Machine, MD Spectramaxm5 and I3 Multifunctional Enzyme Labeling Instrument, MSD Meso Sector S600 Hypersensitive Multi Factor Electrochemiluminescence Aanalyzer. Nearly 100 assays have been developed and verified to detect protein or phosphorylated protein biomarker, and to support PK/ADA macromolecular bioanalysis in various specimens including tissues, cells, plasma, and serum. The assays are widely used in preclinical and clinical pharmacodynamics, macromolecular pharmacokinetics and immunogenicity research of drugs.

PK/PD/ADA/WB/Others

ELISA Platform
Ferritin	EGF
Transferrin	KIM-1
EPO	NGAL
soluble BCMA	HGF
TPO	Elafin
VEGF-A	Reg3A
VEGFR2	sTNFR1
M-CSF	ST2
HIV1 p24	Cotinine
BTK Occupancy	Hepcidin
CTX-I	Glycated Albumin
CTX-II	Complement C3a
Creatinine	Complement C5a
TGF-β1	MMP13
CFD	PGE2
Alpha-1-Microglobulin	CK18-M30, CK18-M65
soluble c-Met	IgE
Mer	Myoglobin
GAS6	Free Glycerol
Protein S/PROS1	5'nucleotidase
Axl	C4a
beta Hydroxybutyrate (β-HB)	FGF19
Acetoacitate	C4
Phospho-CRKL	Phospho-FAK/Total-FAK
Phospho-c-Met/Total-c-Met	Phospho-FLT3 (CST Kit)/Total-FLT3 (R&D SYSTEMS Kit)
Phospho-FGFR1/Total-FGFR1	Phospho-FLT3 (CST Kit)/Total-FLT3 (R&D SYSTEMS Kit)

MSD Platform
soluble PD-L1	U-PLEX(IL-2, IL-4, IL-6, IL-18, IL-23, IFN-γ, TNF-α)
V-PLEX(TNF-α, IFN-γ, IL-10, IL-6, IL-2)	V-PLEX(IL-1β, IL-6, IL-10)
V-PLEX Proinflammatory Panel 1 Human Kit (IFN-γ, IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12p70, IL-13, TNF-α)	V-PLEX(IFN-γ, IL-2, IL-8, IL-10)
soluble CD137	V-PLEX(GM-CSF, IL-15)
soluble CTLA-4	IL-10
VEGF-A	IL-6
HGF	MCP-1
KDR/sVEGFR2	U-PLEX(CCL17, CXCL5, CXCL11, CXCL10, CCL4, CCL2, CXCL8, CCL11, CCL3, CXCL1)
BAFF	R-PLEX(CXCL9/MIG)
U-PLEX (IL-8, VEGFA)	Phospho-ERK1/2/Total-ERK1/2
CXCL13/BCA-1	Phospho-S6RP/Total-S6RP
vWF	Phospho-STAT3
YKL-40	Phospho-Met/Total Met
Calbindin D28K	Granzyme B, IFN-γ, IL-6， IL-12/IL-23p40, IP-10, LAG3, PD-L1(Epitope 1)、CXCL9
BMP-7	V-PLEX Human Cytokine 30-Plex Kit （Contains 310-plex panel）(Eotaxin, Eotaxin-3, GM-CSF, IFN-γ, IL-10, IL-12/IL-23p40, IL-12p70, IL-13, IL-15, IL-16, IL-17A, IL-1α, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-8 (HA), IP-10, MCP-1, MCP-4, MDC, MIP-1α, MIP-1β, TARC, TNF-α, TNF-β, VEGF-A)
IGF-1	U-PLEX Human Cytokine 20-Plex Kit （Contains 3panel）(IFN-α2a, IFN-β, IFN-γ, IL-2, IL-2Rα, IL-5, IL-6, IL-8, IL-10, IL-12, IL-12p70, IL-17C, IL-21, IL-29, IL-33, IP-10, MCP-1, MIP-1α, TNF-α, TRAIL)
FGF23
TGF-β1

Representative Testing Manual	PK/ADA
CAR-T CD19 HAMA	ADA
Car-T CD7	ADA
Inactivated virus vaccine specific IgG	ADA
Herceptin	PK /ADA
Herceptin-MMAE	PK /ADA
Herceptin-DM1	PK /ADA
Avastin	PK
Adalimumab	PK
PEG-Tα1	PK
PEG-rhG-CSF	PK
Exenatide	PK ,ADA
Fc fusion protein	PK
Supaglutide	PK
Car-T CD8 CD104	PK
bFGF	PK
Calcitonin salmon	PK
Pharma Projects	ADA
	PK
	TK
	BE/Biosimilar
	PD

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